CBS confirmed to E! News Wednesday that former "House" star Amber Tamblyn has been signed to play Charlie Harper's long-lost daughter on "Two and a Half Men" when it returns for an 11th season this fall.

Tamblyn will guest on at least five episodes as Jenny, whom show creator Chuck Lorre describes as "a pretty remarkably strong and ballsy character," adding that she's "a chip off the old block," referring to her father's womanizing ways.

However, Lorre said that Tamblyn's character is bisexual, not a lesbian, telling E! News that "The idea that she loves women seems to be something that just felt right."

Other changes to the show include the departure of Angus T. Jones as a full-time castmember, and that he'll no longer appear in the show's opening credits. Jones notoriously trashed the show earlier this year, but Lorre says,  "I'm hopeful that he'll carve out some time to do some episodes and he's certainly not written out of the series by any means."

"Two and a Half Men" will kick off its new season Sept. 26 on CBS.