Jon Stewart's departure from his desk at The Daily Show has left not just an empty place in fans' hearts, but also celebrities and politicians who've followed and/or guested on the show for the last sixteen years. Here's a sampling of celebrity responses to this sad event.

Jerry Seinfeld: Wish you all best, dude. Keep taking those fantastic pauses, inhales, slow squint then drop funny line... Love you, man.

Ed Helms: Can't decide what's worse, Jon leaving @TheDailyShow or global warming.

Hilary Clinton: Missing Jon Stewart already. -H

Ellen Degeneres: No one has made news so funny, or made comedy such big news.

NYC Mayor Bill de Blasio: Now the only comic relief left on TV is Fox News.

Patton Oswalt: You used outrageousness to aim outrage where it needed to go. So , and thank you.

Barack Obama: "You've been a great gift to the country." —President Obama to Jon Stewart on @TheDailyShow

Ryan Seacrest: Here's to your own moment of zen, jon stewart. We’ll miss u

Nick Kroll: Jon Stewart & @TheDailyShow inspired me more than anything on TV at the time I decided to pursue comedy as a career.